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Bio-K Forte Caps 60 Capsules Biotics Research

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Bio-K Forte Caps 60 Capsules by Biotics Research
Price: $19.97
Item Number: 1017
Brand: Biotics Research
UPC: mpn 1017
Condition: New
tax free
Two forms of vitamin K are naturally occurring; vitamin K1 known as phylloquinone and vitamin K2 referred to as menaquionone. K1 and K2 differ in their structural arrangement with K1 compounds possessing a saturated side chain while the K2 family of compounds has an unsaturated side chain. In addition to their structural differences they also target different tissues.

The K1 family of compounds (phylloquinones) synthesized in green leafy vegetables and in plant leaves is the primary dietary source of vitamin K estimated to contribute about 40-50% of the total dietary intake. Alternative sources of phylloquinones include meals prepared with phylloquinone-rich oils such as soybean cottonseed canola and olive oils estimated to contribute ~15% of the dietary phylloquinine intake. In relation to health the phylloquinines are typically associated with bone mineralization. Subobtimal levels are correlated to an increase in both osteoporotic fracture rates and osteoporosis. The former has been correlated with a more “Westernized” lifestyle which is typically high in protein. Consequently as a result of a high protein diet an increase in the net renal acid excretion has been observed which in turn increases the excretion of urinary calcium. Even in healthy individuals it has been
observed that there is a substantial fraction of undercarboxylated or incompletely carboxylated species of osteocalcin and matrix Gla protein (MGP) in circulation indicating a quantifiable deficiency in vitamin K.

Menaquinones collectively referred to as vitamin K2 are structurally defined by their content of isoprene units.
Those of dietary relevance have from four (MK-4) through ten (MK-10) isoprenoid residues. Unlike phylloquinones menaquinones are present in both human and animal tissues and are largely synthesized by the gut microflora. Overall they contribute only a very small portion to the daily vitamin K supply except in cultures consuming large amounts of fermented soybean products which contains significant amounts of MK-6 and MK-8.

Vitamin K2 is associated with beneficial cardiovascular attributes and is believed to suppress arterial calcification via γ-carboxylation of matrix glutamic acid residues. Vascular calcification is considered a major complication in cardiovascular disease as well as an independent risk factor for both myocardial infarction and ultimately death. Experimental inactivation of MGP by treatment with a vitamin K antagonist has been demonstrated to result in rapid arterial calcification. However this attribute is negated with high doses of vitamin K as demonstrated by its ability to result in the regression of arterial calcification. The forms commonly utilized in nutritional supplements are the MK-4 and MK-7. Although both are effective MK-4 has a very short half-life about one hour whereas the half-life of MK-7 is much longer typically about three days.

As a cofactor in the γ-glutamyl carboxylation pathway
the vitamin K dependent (VKD) proteins play a physiologically diverse role in cellular proliferation. These proteins also play a very important role in the activation of the coagulation cascade and in the maintenance of both the flow and the structural integrity of vascular tissues. The VKD proteins although traditionally associated with blood coagulation are currently known to be present in virtually every tissue and evidence indicates that they play a significant role in bone mineralization and metabolism including bone development and maintenance apoptosis phagocytosis growth control chemotaxis signal transduction and arterial calcification. In addition to their role in arterial calcification they have also been correlated to cardiovascular health by virtue of their association with the coagulation cascade particularly the recently described halotype vitamin K epoxide reductase complex subunit 1 (VKORC1). Currently the daily reference intake (DRI) for vitamin K is 90 mcg/day for adult females and 120 mcg/day for adult males. However as indicated above this value may be too low to meet daily physiological needs. Vitamin K2 intakes of 45 mcg/day have been recommended by clinical
nutritionists. Since approximately 60-70% of the daily
dietary intake is lost via excretion the need for a continuous dietary supply in an effort to maintain adequate tissue reserves is pertinent.

Serving size: 1 capsule

Amount per servings %Daily Value

Vitamin K (as menaquionine-7 phytonadione) 550 mcg 688%

Superoxide Disumtase (from vegetable culture) 60 mcg *

Catalase (form vegetable culture+) 60 mcg *

*Daily Valeue not established

Other ingredients: Capsule shell (gelatin and water) and magnesium stearate (vegetable source).

+ Specially grown biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase dehydrated at low temperature to preserve associated enzyme factors.

Each capsule supplies Vitamin K as menaquinone-7 and phytonadione in a 1:10 ratio.

One (1) capsule each day as a dietary supplement or as otherwise directed by a healthcare professional.

Those taking warfarin should avoid supplementation with Vitamin K unless specifically recommended and monitored by their physician. Pregnant and nursing mothers should avoid supplemental intakes higher than the RDA (65 mcg) unless specifically recommended and monitored by their physician.

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